Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax

@article{Cho2010Transglutaminase2I,
  title={Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax},
  author={Sung-Yup Cho and Jin-Haeng Lee and Han-Dong Bae and Eui Man Jeong and Gi-Yong Jang and Chai-Wan Kim and Dong-Myung Shin and Ju-Hong Jeon and In-Gyu Kim},
  journal={Experimental & Molecular Medicine},
  year={2010},
  volume={42},
  pages={639-650}
}
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and activation of Ca2+-dependent enzymes. Transglutaminase 2 (TG2) is a Ca2+-dependent enzyme that catalyzes transamidation reaction producing cross-linked and polyaminated proteins. TG2 activity is known to be involved in the apoptotic process. However, the pro-apoptotic role of… CONTINUE READING
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