Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens

@inproceedings{Tian2009TransgenicallyIG,
  title={Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens},
  author={Jide Tian and Hoa N. Dang and Harald von Boehmer and Elmar Jaeckel and Daniel L Kaufman},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE To study how tolerance to GAD65 affects the development of autoimmunity to other beta-cell autoantigens (beta-CAAs) in GAD65-transgenic (GAD-tg) NOD mice. RESEARCH DESIGN AND METHODS We used ELISPOT to characterize the frequency and functional phenotype of T-cell responses to GAD65 and other beta-CAAs at different ages in GAD-tg mice and their NOD mouse littermates. RESULTS In young GAD-tg mice, Th1 responses to GAD65's dominant determinants were 13-18% of those in young NOD mice… CONTINUE READING

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