Transgenic silkworms that weave recombinant proteins into silk cocoons

  title={Transgenic silkworms that weave recombinant proteins into silk cocoons},
  author={Masahiro Tomita},
  journal={Biotechnology Letters},
  • M. Tomita
  • Published 1 April 2011
  • Chemistry, Medicine
  • Biotechnology Letters
As a result of breeding for more than 4,000 years, the silkworm, Bombyx mori, has acquired the ability to synthesize bulk amounts of silk proteins in its silk glands. To utilize this capacity for mass production of useful proteins, transgenic silkworms were generated that synthesized recombinant proteins in the silk gland and secreted them into the silk cocoon. The silk gland is classified into two main regions: the posterior (PSG) and the middle silk gland (MSG). By controlling the expressed… 

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