Transgenic silkworms (Bombyx mori) produce recombinant spider dragline silk in cocoons

@article{Wen2009TransgenicS,
  title={Transgenic silkworms (Bombyx mori) produce recombinant spider dragline silk in cocoons},
  author={Hongxiu Wen and Xiqian Lan and Yuansong Zhang and Tianfu Zhao and Yujun Wang and Zenta Kajiura and Masao Nakagaki},
  journal={Molecular Biology Reports},
  year={2009},
  volume={37},
  pages={1815-1821}
}
Spider dragline silk is a unique fibrous protein with a combination of tensile strength and elasticity, but the isolation of large amounts of silk from spiders is not feasible. In this study, we generated germline-transgenic silkworms (Bombyx mori) that spun cocoons containing recombinant spider silk. A piggyBac-based transformation vector was constructed that carried spider dragline silk (MaSp1) cDNA driven by the sericin 1 promoter. Silkworm eggs were injected with the vector, producing… 
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