Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR).

@article{Wehr2009TransgenicSO,
  title={Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR).},
  author={Michael Wehr and Ute Hostick and Michael Kyweriga and Ailian Tan and Aldis P. Weible and Haiyan Wu and Wei Wu and Edward M. Callaway and Clifford G. Kentros},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 4},
  pages={2554-62}
}
The mammalian brain is an enormously complex set of circuits composed of interconnected neuronal cell types. The analysis of central neural circuits will be greatly served by the ability to turn off specific neuronal cell types while recording from others in intact brains. Because drug delivery cannot be restricted to specific cell types, this can only be achieved by putting "silencer" transgenes under the control of neuron-specific promoters. Towards this end we have created a line of… CONTINUE READING

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