Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.

@article{Nath2005TransgenicSM,
  title={Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.},
  author={Karl A Nath and Joseph P Grande and Anthony J. Croatt and Elena M Frank and Noel M. Caplice and Robert P. Hebbel and Zvonimir S. Katu{\vs}i{\'c}},
  journal={The American journal of pathology},
  year={2005},
  volume={166 4},
  pages={963-72}
}
Ischemic injury is invoked as a mechanism contributing to end-organ damage and other complications of sickle cell disease (SCD). However, the intrinsic sensitivity of tissues in SCD to ischemic insults has never been addressed. We examined the effect of renal ischemia in a transgenic mouse expressing human sickle hemoglobin. Twenty-four hours after bilateral, total renal artery occlusion for 15 minutes, transgenic sickle mice exhibited worse renal function and more marked histological injury… CONTINUE READING

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