Transgenic rice seeds accumulating recombinant hypoallergenic birch pollen allergen Bet v 1 generate giant protein bodies.

@article{Wang2013TransgenicRS,
  title={Transgenic rice seeds accumulating recombinant hypoallergenic birch pollen allergen Bet v 1 generate giant protein bodies.},
  author={Shu-yi Wang and Hideyuki Takahashi and Hiroyuki Kajiura and Taiji Kawakatsu and Kazuhito Fujiyama and F. Takaiwa},
  journal={Plant & cell physiology},
  year={2013},
  volume={54 6},
  pages={917-33}
}
A versatile hypoallergenic allergen derivative against multiple allergens is an ideal tolerogen for allergen-specific immunotherapy. Such a tolerogen should exhibit high efficacy, without side effects, when administered at high doses and should be applicable to several allergens. Tree pollen chimera 7 (TPC7), a hypoallergenic Bet v 1 tolerogen against birch pollen allergy, was previously selected by DNA shuffling of 14 types of Fagales tree pollen allergens. In this study, transgenic rice seed… CONTINUE READING
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