Transgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutant

@article{Steffensen1999TransgenicRO,
  title={Transgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutant},
  author={Scott C. Steffensen and Steven J. Henriksen and Michael C. Wilson},
  journal={Brain Research},
  year={1999},
  volume={847},
  pages={186-195}
}
Many of the molecular components constituting the exocytotic machinery responsible for neurotransmitter release have been identified, yet the precise role played by these proteins in synaptic transmission, and their impact on neural function, has not been resolved. The mouse mutation coloboma is a contiguous gene defect that leads to electrophysiological and behavioral deficits and includes the gene-encoding SNAP-25, an integral component of the synaptic vesicle-docking/fusion core complex. The… Expand
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