Transgenic rat model of Huntington's disease.

@article{Hrsten2003TransgenicRM,
  title={Transgenic rat model of Huntington's disease.},
  author={Stephan von H{\"o}rsten and Ina Schmitt and Huu Phuc Nguyen and Carsten Holzmann and Thorsten L Schmidt and Thomas Walther and Michael Bader and Reinhard Dr. med Pabst and Philipp Kobbe and Jana Krotova and Detlef Stiller and A. K. Kask and Annika Vaarmann and Silvia Rathke-Hartlieb and J{\"o}rg Bernhard Schulz and Ute Grasshoff and I. Bauer and Ana Maria Menezes Vieira-Saecker and Martin Paul and Lesley Jones and Katrin S Lindenberg and Bernhard G. Landwehrmeyer and Andreas Bauer and Xiao-Jiang Li and Olaf Riess},
  journal={Human molecular genetics},
  year={2003},
  volume={12 6},
  pages={
          617-24
        }
}
Huntington's disease (HD) is a late manifesting neurodegenerative disorder in humans caused by an expansion of a CAG trinucleotide repeat of more than 39 units in a gene of unknown function. Several mouse models have been reported which show rapid progression of a phenotype leading to death within 3-5 months (transgenic models) resembling the rare juvenile course of HD (Westphal variant) or which do not present with any symptoms (knock-in mice). Owing to the small size of the brain, mice are… CONTINUE READING

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