Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach–Merritt syndrome

@article{Kitajima2005TransgenicRW,
  title={Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach–Merritt syndrome},
  author={Shuji Kitajima and Enqi Liu and Masatoshi Morimoto and Tomonari Koike and Ying Di Yu and Teruo Watanabe and Shigehiko Imagawa and Jianglin Fan},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={1517-1527}
}
Clinical studies have provided ample evidence that high (either systemic or local) levels of vascular endothelial growth factor (VEGF) are associated with several pathophysiological disorders, including hemangiomas. To investigate whether elevated VEGF expression could directly affect these disorders, we created a transgenic (Tg) rabbit model with increased hepatic expression of the human VEGF165 transgene under the control of the human α-antitrypsin promoter. Tg rabbits exhibited marked… CONTINUE READING

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