Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.

@article{Fan2001TransgenicRE,
  title={Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet.},
  author={Jianglin Fan and Hiroaki Shimoyamada and Huijun Sun and Santica S Marcovina and Kazuo Honda and Teruo Watanabe},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 1},
  pages={88-94}
}
High lipoprotein(a) [Lp(a)] levels constitute an independent risk factor for the development of atherosclerosis. However, the relationship between Lp(a) and atherosclerosis is not fully understood. To examine the effect of Lp(a) on the development of atherosclerosis, we studied transgenic rabbits expressing human apolipoprotein(a) [apo(a)], which was assembled into Lp(a) in the plasma. Human apo(a) transgenic rabbits fed a 0.3% cholesterol diet for 16 weeks had more extensive atherosclerotic… CONTINUE READING

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