Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

@article{Ma1997TransgenicPE,
  title={Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance},
  author={S.-W. Ma and D Y Zhao and Z.-Q. Yin and Rinee Mukherjee and Bhagi Singh and H.-Y. Qin and Calvin R. Stiller and Anthony M Jevnikar},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={793-796}
}
Oral administration of protein can induce antigen-specific immune hyporesponsiveness1. However, the utility of oral tolerance to autoantigens in the treatment of autoimmune diseases may be limited when candidate autoantigens cannot be produced by conventional systems in quantities sufficient for clinical studies. Plants may be ideally suited for this purpose, as they can synthesize, glycosylate and assemble mammalian proteins to provide huge quantities of relatively low cost soluble proteins2… CONTINUE READING

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