Transgenic overexpression of dystroglycan does not inhibit muscular dystrophy in mdx mice.

@article{Hoyte2004TransgenicOO,
  title={Transgenic overexpression of dystroglycan does not inhibit muscular dystrophy in mdx mice.},
  author={Kwame Hoyte and Vianney Jayasinha and Bing Xia and Paul T. Martin},
  journal={The American journal of pathology},
  year={2004},
  volume={164 2},
  pages={711-8}
}
Recently, there have been a number of studies demonstrating that overexpression of molecules in skeletal muscle can inhibit or ameliorate aspects of muscular dystrophy in the mdx mouse, a model for Duchenne muscular dystrophy. Several such studies involve molecules that increase the expression of dystroglycan, an important component of the dystrophin-glycoprotein complex. To test whether dystroglycan itself inhibits muscular dystrophy in mdx mice, we created dystroglycan transgenic mdx mice (DG… CONTINUE READING

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