Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions.

@article{Benavides2011TransgenicOO,
  title={Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions.},
  author={Fernando J. Benavides and Jorge Blando and Carlos J. Perez and Rachana Garg and Claudio J. Conti and John DiGiovanni and Marcelo G Kazanietz},
  journal={Cell cycle},
  year={2011},
  volume={10 2},
  pages={268-77}
}
It is well established that protein kinase C (PKC) isozymes play distinctive roles in mitogenic and survival signaling as well as in cancer progression. PKCε, the product of the PRKCE gene, is up-regulated in various types of cancers including prostate, lung and breast cancer. To address a potential role for PKCs in prostate cancer progression we generated three mouse transgenic lines expressing PKCα, PKCδ, or PKCε in the prostate epithelium under the control of the rat probasin (PB) promoter… CONTINUE READING
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