Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion

@article{Ohba2004TransgenicMO,
  title={Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion},
  author={Norihiro Ohba and Sumiko Kiryu-Seo and Mitsuyo Maeda and Michinari Muraoka and Hiroshi Kiyama},
  journal={Neuroscience Letters},
  year={2004},
  volume={359},
  pages={159-162}
}
Transgenic mouse lines expressing the active form Akt gene under the control of the damage-induced neuronal endopeptidase (DINE) promoter were made from three different founder mice, and its neuroprotective potential against ischemic brain damage was investigated. Twenty-four hours after middle cerebral artery occlusion, two DINE-Akt-transgenic mouse lines displayed reductions of the infarcted area by 35% compared to the wild-type littermate. RT-PCR assays showed a high level of transgene in… CONTINUE READING
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