Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome

@article{Weiher1990TransgenicMM,
  title={Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome},
  author={Hans Weiher and Tetsuo Noda and Douglas A. Gray and Arlene H Sharpe and Rudolf Jaenisch},
  journal={Cell},
  year={1990},
  volume={62},
  pages={425-434}
}
Transgenic mouse strains carrying proviruses were generated by exposing mouse embryos to a recombinant retrovirus. Animals carrying a single provirus were intercrossed to derive mice homozygous for a given proviral insertion. Adult mice homozygous for the Mpv17 integration developed nephrotic syndrome and chronic renal failure. Histologically, affected kidneys showed progressive glomerular sclerosis. Similar lesions are seen in patients with progressive renal function deterioration. A probe to… CONTINUE READING
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