Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development.

@article{Matzuk1996TransgenicMT,
  title={Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development.},
  author={Martin M. Matzuk and Tanwar Rajendra Kumar and Wenying Shou and Katherine A. Coerver and Anthony L. Lau and Richard R. Behringer and Milton J. Finegold},
  journal={Recent progress in hormone research},
  year={1996},
  volume={51},
  pages={
          123-54; discussion 155-7
        }
}
With the advent of gene targeting in pluripotent mouse embryonic stem cells, it is now possible to modify the mammalian genome to generate mutant strains of mice with precise genetic mutations. The major goal of my laboratory is to generate transgenic mice to use as physiologic models to study mammalian reproduction and development. The initial focus of our research has been to generate mice deficient in inhibins, activins, activin binding proteins (i.e., follistatin), and activin receptors (i… CONTINUE READING

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