Transgenic models of neurodegenerative diseases

@article{Lee1996TransgenicMO,
  title={Transgenic models of neurodegenerative diseases},
  author={Michael Keith Lee and David R Borchelt and Philip Chuen Yung Wong and Sangram S. Sisodia and Donald L. Price},
  journal={Current Opinion in Neurobiology},
  year={1996},
  volume={6},
  pages={651-660}
}
Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinucleotide repeat diseases, result from a gain of deleterious properties. The disease-specific pathology in transgenic mice demonstrates the utility of these models in elucidating… CONTINUE READING
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