Transgenic models of T-cell self tolerance and autoimmunity.

  title={Transgenic models of T-cell self tolerance and autoimmunity.},
  author={J F A P Miller and Grant Morahan and Robyn M. Slattery and Janette Allison},
  journal={Immunological reviews},
Self-tolerance is generally induced by intrathymic clonal deletion of T cells with reactivity directed to antigens synthesized within the thymus (Kappler et al. 1987, Kisielow et al. 1988). It may also be induced in peripheral T cells when these encounter antigens unique to extra-thymic tissues. Two transgenic models have been particularly useful in the study of peripheral self tolerance: in one model, a known antigen is expressed in a particular extra-thymic site; in the other, the T-cell… CONTINUE READING