Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilites in a water task

  title={Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilites in a water task},
  author={L. Rondi-Reig and Y. Lemaigre-Dubreuil and C. Mont{\'e}cot and D. M{\"u}ller and J. Mariani},
  • L. Rondi-Reig, Y. Lemaigre-Dubreuil, +2 authors J. Mariani
  • Published 2001
  • Psychology, Medicine
  • Neuroscience
  • In the CNS, Bcl-2 is an antiapoptotic gene involved in the regulation of neuronal death. Transgenic mice overexpressing the human gene Bcl-2 (Hu-bcl-2 mice) showed delayed acquisition in two tasks requiring them to find a hidden platform starting from either a random or a constant starting location. The same mice were not deficient in another task requiring them to find a visible platform suggesting that the delay observed was not due to motor, visual or motivational deficits in the water. The… CONTINUE READING
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