Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilites in a water task

@article{RondiReig2001TransgenicMW,
  title={Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilites in a water task},
  author={Laure Rondi-Reig and Yolande Lemaigre‐Dubreuil and C{\'e}line Mont{\'e}cot and Daniel M{\"u}ller and Jean-Claude Martinou and Jean Caston and Jean Mariani},
  journal={Neuroscience},
  year={2001},
  volume={104},
  pages={207-215}
}
In the CNS, Bcl-2 is an antiapoptotic gene involved in the regulation of neuronal death. Transgenic mice overexpressing the human gene Bcl-2 (Hu-bcl-2 mice) showed delayed acquisition in two tasks requiring them to find a hidden platform starting from either a random or a constant starting location. The same mice were not deficient in another task requiring them to find a visible platform suggesting that the delay observed was not due to motor, visual or motivational deficits in the water. The… 
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Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord
  • N. G. Forger
  • Biology, Medicine
    Journal of neuroendocrinology
  • 2009
TLDR
Possible mechanisms by which testosterone may regulate cell death in the nervous system are discussed, as are the behavioural effects of eliminating sex differences in neuronal cell number.
Specific neurodevelopmental damage in mice offspring following maternal inflammation during pregnancy
TLDR
Maternal inflammation specifically impaired distinct forms of learning and memory, but not motor function or exploration in the adult offspring, which may suggest particular sensitivity of the hippocampus and other associated brain regions to inflammatory factors during late embryonic development.
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TLDR
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TLDR
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TLDR
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TLDR
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