Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.

@article{Okamoto1997TransgenicMW,
  title={Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.},
  author={Naoyuki Okamoto and Takao Tobe and Sean Francis Hackett and Hiroaki Ozaki and M A Vinores and William Larochelle and Donald J. Zack and Peter Anthony Campochiaro},
  journal={The American journal of pathology},
  year={1997},
  volume={151 1},
  pages={281-91}
}
Vascular endothelial growth factor (VEGF) has been implicated in retinal neovascularization (NV), but it has been difficult to produce retinal NV with exogenous VEGF. We investigated the effect of increased VEGF expression in the retina using tissue-specific, gain-of-function transgenic mice in which the bovine rhodopsin promoter is coupled to the gene for human VEGF. Three founder mice were obtained and used to generate transgenic lines. One of the lines shows increased expression of VEGF in… CONTINUE READING

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