Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.

@article{Hara2003TransgenicMW,
  title={Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.},
  author={Manami Hara and Xiaoyu Wang and Toshihiko Kawamura and Vytas P. Bindokas and Restituto F. Dizon and Sergio Y. Alcoser and Mark A Magnuson and Graeme I. Bell},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={284 1},
  pages={E177-83}
}
We have generated transgenic mice that express green fluorescent protein (GFP) under the control of the mouse insulin I gene promoter (MIP). The MIP-GFP mice develop normally and are indistinguishable from control animals with respect to glucose tolerance and pancreatic insulin content. Histological studies showed that the MIP-GFP mice had normal islet architecture with coexpression of insulin and GFP in the beta-cells of all islets. We observed GFP expression in islets from embryonic day E13.5… CONTINUE READING
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