Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa

@article{Olsson1992TransgenicMW,
  title={Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa},
  author={Jane E. Olsson and Jon W. Gordon and Basil S. Pawlyk and Dorothy Roof and T. P. Dryja},
  journal={Neuron},
  year={1992},
  volume={9},
  pages={815-830}
}
We inserted into the germline of mice either a mutant or wild-type allele from a patient with retinitis pigmentosa and a missense mutation (P23H) in the rhodopsin gene. All three lines of transgenic mice with the mutant allele developed photoreceptor degeneration; the one with the least severe retinal photoreceptor degeneration had the lowest transgene expression, which was one-sixth the level of endogenous murine rod opsin. Of two lines of mice with the wild-type allele, one expressed… Expand
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