Transgenic mice that express Cre recombinase in hypertrophic chondrocytes.

  title={Transgenic mice that express Cre recombinase in hypertrophic chondrocytes.},
  author={Guan Gen Yang and Fang Cui and Ning Hou and Xuan Cheng and Jishuai Zhang and Youliang Wang and Nan Jiang and Xiang Gao and Xiao Yang},
  volume={42 1},
In order to investigate the physiological control of hypertrophic chondrocytes which present the terminally differentiated form of chondrocytes, we generated a mouse line expressing the Cre recombinase under the control of the mouse type X collagen (Col10a1) promoter. In situ hybridization analysis demonstrated the expression of Col10a1-Cre transgene in hypertrophic chondrocytes of femur at postnatal day 2 (P2). In order to test the excision activity of the Cre recombinase, the Col10a1-Cre… CONTINUE READING

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