Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin.

@article{Eslin2004TransgenicMS,
  title={Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin.},
  author={Don E. Eslin and Chunyan Zhang and Kathleen Jessica Samuels and Lubica Rauova and Li Ping Zhai and Stefan Niewiarowski and Douglas B Cines and M. Poncz and Maria Anna Kowalska},
  journal={Blood},
  year={2004},
  volume={104 10},
  pages={3173-80}
}
The platelet-specific chemokine platelet factor 4 (PF4) is released in large amounts at sites of vascular injury. PF4 binds to heparin with high affinity, but its in vivo biologic role has not been defined. We studied the role of PF4 in thrombosis using heterozygote and homozygote PF4 knock-out mice (mPF4(+/-) and mPF4(-/-), respectively) and transgenic mice overexpressing human PF4 (hPF4(+)). None of these lines had an overt bleeding diathesis, but in a FeCl(3) carotid artery thrombosis model… CONTINUE READING

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References

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Showing 1-10 of 58 references

Platelet Factor 4 upregulates protein C activation relative to TAFI activation. Birmingham, United Kingdom: XIX Congress of The International Society on Thrombosis and Haemostasis; 2003:OC376

LO Mosnier, BN Bouma, JH. Griffin
2003

Platelet secretion

MH Fukami, H Holmsen, MA Kowalska, S. Niewiarowski
2001

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