Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.

@article{Hudert2006TransgenicMR,
  title={Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.},
  author={Christian A Hudert and Karsten Henrich Weylandt and Yan Lu and Jingdong Wang and Song Iee Hong and Axel Dignass and Charles N Serhan and Jing Kang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 30},
  pages={11276-81}
}
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are the precursors of potent lipid mediators and play an important role in regulation of inflammation. Generally, n-6 PUFA promote inflammation whereas n-3 PUFA have antiinflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived proinflammatory eicosanoids. Newly discovered resolvins and protectins are potent antiinflammatory lipid mediators derived directly from n-3 PUFA with… CONTINUE READING
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