Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.

@article{Wang2006TransgenicMO,
  title={Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia.},
  author={Yan Wang and Shelley Ann Phelan and Yefim Manevich and Sheldon I. Feinstein and Aron B. Fisher},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={34 4},
  pages={481-6}
}
Peroxiredoxin 6 (Prd x 6) is a novel peroxidase enzyme that is expressed at a high level in the lung. We tested the hypothesis that transgenic (Tg) mice overexpressing Prd x 6 would exhibit increased resistance to hyperoxia-induced lung injury. Wild-type and Tg mice were exposed to 100% O(2) and evaluated for survival, lung histopathology, total protein… CONTINUE READING