Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis.

Abstract

UNLABELLED The bone phenotype of mice overexpressing MIF was studied. These mice showed decreased trabecular bone, increased bone formation rate, and increased MMP-3, -9, and -13 mRNA expression in the femora and tibias. This model provides evidence of the role played by MIF in bone remodeling and balance in vivo. INTRODUCTION The role of macrophage… (More)

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Cite this paper

@article{Onodera2006TransgenicMO, title={Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis.}, author={Shin Onodera and Satoshi Sasaki and Shigeki Ohshima and Norio Amizuka and Minqi Li and Nobuyuki Udagawa and Kazuharu Irie and Jun Nishihira and Yoshikazu Koyama and Ayako Shiraishi and Harukazu Tohyama and Kazunori Yasuda}, journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research}, year={2006}, volume={21 6}, pages={876-85} }