Transgenic mice overexpressing nesfatin/nucleobindin-2 are susceptible to high-fat diet-induced obesity

Abstract

Background:Nesfatin/Nucleobindin-2 (Nesf/NUCB2), a precursor of nesfatin-1, an anorexigenic protein, is ubiquitously expressed in peripheral tissues in addition to the hypothalamus. However, the role of intracellular Nesf/NUCB2 has not been established in the periphery.Methods:Nesf/NUCB2-transgenic (Tg) mice were generated, and chronological changes of body… (More)
DOI: 10.1038/nutd.2015.42

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