Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.

  title={Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.},
  author={Konrad R. G{\"o}tz and Julia U. Sprenger and Ruwan K. Perera and Julia H. Steinbrecher and Stephan E. Lehnart and Michaela Kuhn and Julia Gorelik and Jean-Luc Balligand and Viacheslav O Nikolaev},
  journal={Circulation research},
  volume={114 8},
RATIONALE 3',5'-Cyclic guanosine monophosphate (cGMP) is an important second messenger that regulates cardiac contractility and protects the heart from hypertrophy. However, because of the lack of real-time imaging techniques, specific subcellular mechanisms and spatiotemporal dynamics of cGMP in adult cardiomyocytes are not well understood. OBJECTIVE Our aim was to generate and characterize a novel cGMP sensor model to measure cGMP with nanomolar sensitivity in adult cardiomyocytes… CONTINUE READING
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