Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.

@article{Liu1993TransgenicME,
  title={Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.},
  author={Marjorie L M Liu and E. Michael Gibbs and Scott McCoid and A. Milici and Hans A Stukenbrok and R Kirk McPherson and Judith L. Treadway and Jeffrey E. Pessin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 23},
  pages={11346-50}
}
To examine the physiological role of the GLUT4/muscle-fat specific facilitative glucose transporter in regulating glucose homeostasis, we have generated transgenic mice expressing high levels of this protein in an appropriate tissue-specific manner. Examination of two independent founder lines demonstrated that high-level expression of GLUT4 protein resulted in a marked reduction of fasting glucose levels (approximately 70 mg/dl) compared to wild-type mice (approximately 130 mg/dl… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…