Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.

@article{Ferrero1993TransgenicME,
  title={Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.},
  author={Enza Ferrero and Demao Jiao and Ben-zion Tsuberi and Luisa Tesio and Guobin Rong and Alain Haziot and Sanna M. Goyert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 6},
  pages={2380-4}
}
In vitro studies have previously shown that the myelomonocytic differentiation antigen CD14 is a receptor for a complex consisting of lipopolysaccharide (LPS) and LPS-binding protein. To investigate the role of CD14 in vivo and its relationship to induction of LPS-induced endotoxin shock, transgenic mice expressing human CD14 were produced. These mice express human CD14 strongly on the surface of their monocytes, neutrophils, and Thy-1(+) lymphocytes and are hypersensitive to LPS, as evidenced… CONTINUE READING

From This Paper

Topics from this paper.
74 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

Similar Papers

Loading similar papers…