Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.

  title={Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.},
  author={Enza Ferrero and Demao Jiao and Ben-zion Tsuberi and Luisa Tesio and Guobin Rong and Alain Haziot and Sanna M. Goyert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 6},
In vitro studies have previously shown that the myelomonocytic differentiation antigen CD14 is a receptor for a complex consisting of lipopolysaccharide (LPS) and LPS-binding protein. To investigate the role of CD14 in vivo and its relationship to induction of LPS-induced endotoxin shock, transgenic mice expressing human CD14 were produced. These mice express human CD14 strongly on the surface of their monocytes, neutrophils, and Thy-1(+) lymphocytes and are hypersensitive to LPS, as evidenced… CONTINUE READING

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