Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter.

@article{Liu2003TransgenicME,
  title={Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter.},
  author={Hongyan Liu and Toshiro Kishi and Aaron G Roseberry and Xiaoli Cai and Charlotte E. Lee and Jason M Montez and Jeffrey M. Friedman and Joel K Elmquist},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 18},
  pages={7143-54}
}
The melanocortin-4 receptor (MC4-R) is an important regulator of energy homeostasis, and evidence suggests that MC4-R-expressing neurons are downstream targets of leptin action. MC4-Rs are broadly expressed in the CNS, and the distribution of MC4-R mRNA has been analyzed most extensively in the rat. However, relatively little is known concerning chemical profiles of MC4-R-expressing neurons. The extent to which central melanocortins act presynaptically or postsynaptically on MC4-Rs is also… CONTINUE READING
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