Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene.

@article{Passananti2010TransgenicME,
  title={Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene.},
  author={Claudio Passananti and Nicoletta Corbi and Annalisa Onori and Maria Grazia di Certo and Elisabetta Mattei},
  journal={Methods in molecular biology},
  year={2010},
  volume={649},
  pages={183-206}
}
Zinc finger (ZF) proteins belonging to the Cys2-His2 class provide a simple and versatile framework to design novel artificial transcription factors (ATFs) targeted to the desired genes. Our work is based on ZF ATFs engineered to up-regulate the expression level of the dystrophin-related gene utrophin in Duchenne muscular dystrophy (DMD). In particular, on the basis of the "recognition code" that defines specific rules between zinc finger primary structure and potential DNA-binding sites we… CONTINUE READING
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Utrophin upregulation by an artificial transcription factor in transgenic mice

  • E. Mattei, N. Corbi, +11 authors C. Passananti
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