Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.

@article{Castellani2006TransgenicME,
  title={Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.},
  author={Lawrence W. Castellani and James Jinho Chang and Xuping Wang and Aldons J. Lusis and Wanda F. Reynolds},
  journal={Journal of lipid research},
  year={2006},
  volume={47 7},
  pages={
          1366-77
        }
}
  • Lawrence W. Castellani, James Jinho Chang, +2 authors Wanda F. Reynolds
  • Published in Journal of lipid research 2006
  • Biology, Medicine
  • Myeloperoxidase (MPO) is an oxidant-generating enzyme present in macrophages at atherosclerotic lesions and implicated in coronary artery disease (CAD). Although mouse models are important for investigating the role of MPO in atherosclerosis, neither mouse MPO nor its oxidation products are detected in lesions in murine models. To circumvent this problem, we generated transgenic mice expressing two functionally different human MPO alleles, with either G or A at position -463, and crossed these… CONTINUE READING

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