Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs

Abstract

Cre/lox P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreERT) allow temporal control of Cre activity. In this study, we have generated two distinct transgenic mouse lines expressing CreERT, which show 4… (More)
DOI: 10.1186/1423-0127-16-2

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