Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.

@article{Young1999TransgenicMD,
  title={Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.},
  author={Matthew R. Young and Jonathan J. Li and Mercedes Rinc{\'o}n and Richard A Flavell and Bangalore K Sathyanarayana and Rosemarie Hunziker and Nancy Colburn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 17},
  pages={
          9827-32
        }
}
Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced transformation in mouse epidermal JB6 cells and for progression in mouse and human keratinocytes. Until now, the question of whether AP-1 transactivation is required for carcinogenesis in vivo has remained unanswered, as has the issue of functionally significant target genes. To address these issues we have… CONTINUE READING

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