Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.

@article{Shyamala1998TransgenicMC,
  title={Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.},
  author={G. Shyamala and X. Yang and G. Silberstein and M. Barcellos-Hoff and E. Dale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 2},
  pages={
          696-701
        }
}
  • G. Shyamala, X. Yang, +2 authors E. Dale
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
In this report we document the creation of transgenic mice in which the native ratio of A and B forms of progesterone receptor (PR) has been altered by the introduction of additional A form as transgene. We also show that in these mice there is an aberration in mammary development. In ovariectomized prepubertal PR-A transgenic mice, end buds with unusual morphology persist after ovariectomy, and in young adult nonovariectomized mice, mammary glands have extensive lateral branching. The glands… Expand
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