Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.

@article{Wong1997TransgenicMB,
  title={Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.},
  author={Randall C. Wong and Vyacheslav V Vasilyev and Yi Tian Ting and David Ivan Kutler and Mark C. Willingham and Bruce D. Weintraub and S-y Cheng},
  journal={Molecular medicine},
  year={1997},
  volume={3 5},
  pages={
          303-14
        }
}
BACKGROUND Resistance to thyroid hormone (RTH) is a syndrome characterized by refractoriness of the pituitary and/or peripheral tissues to the action of thyroid hormone. Mutations in the thyroid hormone receptor beta (TR beta) gene result in TR beta 1 mutants that mediate the clinical phenotype by interfering with transcription of thyroid hormone-regulated genes via a dominant negative effect. In this study, we developed transgenic mice harboring PV, a potent dominant negative human mutant TR… CONTINUE READING

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