Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood.

@article{Marrelli2007TransgenicMM,
  title={Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood.},
  author={Mauro Toledo Marrelli and Chaoyang Li and Jason L. Rasgon and Marcelo Jacobs-Lorena},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={5580-3}
}
The introduction of genes that impair Plasmodium development into mosquito populations is a strategy being considered for malaria control. The effect of the transgene on mosquito fitness is a crucial parameter influencing the success of this approach. We have previously shown that anopheline mosquitoes expressing the SM1 peptide in the midgut lumen are impaired for transmission of Plasmodium berghei. Moreover, the transgenic mosquitoes had no noticeable fitness load compared with nontransgenic… CONTINUE READING
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