Transgenic livers expressing mitochondrial and cytosolic CK: mitochondrial CK modulates free ADP levels.

@article{Askenasy2002TransgenicLE,
  title={Transgenic livers expressing mitochondrial and cytosolic CK: mitochondrial CK modulates free ADP levels.},
  author={Nadir Askenasy and Alan P. Koretsky},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 2},
  pages={
          C338-46
        }
}
The function of creatine kinase (CK) and its effect on phosphorus metabolites was studied in livers of transgenic mice expressing human ubiquitous mitochondrial CK (CK-Mit) and rat brain CK (CK-B) isoenzymes and their combination. (31)P NMR spectroscopy and saturation transfer were recorded in livers of anesthetized mice to measure high-energy phosphates and hepatic CK activity. CK reaction velocity was related to total enzyme activity irrespective of the isoenzyme expressed, and it increased… CONTINUE READING

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