Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.

@article{French1997TransgenicEO,
  title={Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.},
  author={M B French and Janette Allison and David S Cram and Helen E. Thomas and Majella Dempsey-Collier and Ana Kris da Silva and Harry M Georgiou and Thomas W. H. Kay and Leonard C. Harrison and Andrew M. Lew},
  journal={Diabetes},
  year={1997},
  volume={46 1},
  pages={34-9}
}
IDDM in humans and in nonobese diabetic (NOD) mice is a T-cell-dependent autoimmune disease in which the beta-cells of the pancreatic islets are destroyed. Several putative beta-cell autoantigens have been identified, but insulin and its precursor, proinsulin, are the only ones that are beta-cell specific. (Pro)insulin may be a key autoantigen in IDDM. To address the role of proinsulin in the development of IDDM, we generated NOD mice transgenic for the mouse proinsulin II gene driven off a… CONTINUE READING

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