Transgenic expression of leukemia inhibitory factor inhibits both rod and cone gene expression. Gp130 regulates cone gene expression.

@article{Ash2006TransgenicEO,
  title={Transgenic expression of leukemia inhibitory factor inhibits both rod and cone gene expression. Gp130 regulates cone gene expression.},
  author={John D Ash and Dianca R. Graham},
  journal={Advances in experimental medicine and biology},
  year={2006},
  volume={572},
  pages={
          147-53
        }
}
Leukemia inhibitory factor (LIF) is a member of the interleukin 6 (IL-6) family of cytokines, which also includes oncostatin-M, ciliary neurotrophic factor (CNTF), interleukin-11, and cardiotrophin-1. Members of this family are grouped together based on activation of a common tyrosine kinase receptor, gp130. (Ip et al, 1992) The expression of activating ligands of gp130, including LIF and CNTF, have been localized to Muller glial cells and microglial cells in the retina. (Harada et al, 2002… CONTINUE READING