Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

@article{Strowig2011TransgenicEO,
  title={Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.},
  author={Till Strowig and Anthony Rongvaux and Chozhavendan Rathinam and Hitoshi Takizawa and Chiara Borsotti and William F Philbrick and Elizabeth E. Eynon and Markus G. Manz and Richard A Flavell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 32},
  pages={13218-23}
}
Transplantation of human hematopoietic stem cells into severely immunocompromised newborn mice allows the development of a human hematopoietic and immune system in vivo. NOD/scid/γ(c)(-/-) (NSG) and BALB/c Rag2(-/-)γ(c)(-/-) mice are the most commonly used mouse strains for this purpose and a number of studies have demonstrated the high value of these model systems in areas spanning from basic to translational research. However, limited cross-reactivity of many murine cytokines on human cells… CONTINUE READING
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