Transgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.

@article{Scherer2005TransgenicEO,
  title={Transgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.},
  author={Steven S. Scherer and Y Xu and Albee Messing and Klaus Willecke and Kenneth H. Fischbeck and Linda Jo Bone Jeng},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 6},
  pages={1550-9}
}
Mutations in Gap Junction beta1 (GJB1), the gene encoding the gap junction protein connexin32 (Cx32), cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We investigated the possibility that the expression of mutant Cx32 in other cells besides myelinating Schwann cells contributes to the development of demyelination. Human Cx32 was expressed in transgenic mice using a rat myelin protein zero (Mpz) promoter, which is exclusively expressed by… CONTINUE READING
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