Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

@article{Sevenich2011TransgenicEO,
  title={Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice},
  author={Lisa Sevenich and Fee Werner and Mieczyslaw Gajda and Uta Schurigt and Cornel Sieber and S M{\"u}ller and Marie Follo and Christoph Jonathan Peters and Thomas Reinheckel},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={54-64}
}
Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients. In order to model high CTSB expression in mammary cancer, transgenic mice expressing human CTSB were crossed with transgenic polyoma virus middle T oncogene breast cancer mice (mouse mammary tumor virus-PymT), resulting in a 20-fold increase in cathepsin B activity in the tumors of double-transgenic animals. CTSB expression did not affect tumor onset, but CTSB… CONTINUE READING