Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.

@article{Findlay2002TransgenicEO,
  title={Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.},
  author={Geoffrey S. Findlay and Marilee J. Wick and Maria Paola Mascia and Diana Wallace and Gary W. Miller and R. Adron Harris and Yuri A. Blednov},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={300 2},
  pages={526-34}
}
Glycine receptors (GlyRs) are pentameric ligand-gated ion channels that inhibit neurotransmission in the adult brainstem and spinal cord. GlyR function is potentiated by ethanol in vitro, and a mutant GlyR subunit alpha(1)(S267Q) is insensitive to the potentiating effects of ethanol. To test the importance of GlyR for the actions of ethanol in vivo, we constructed transgenic mice with this mutation. Under the control of synapsin I regulatory sequences, transgenic expression of S267Q mutant GlyR… CONTINUE READING