Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model.

@article{Deleo2000TransgenicEO,
  title={Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model.},
  author={Joyce A Deleo and Maria D. Rutkowski and Anna Stalder and Iain L Campbell},
  journal={Neuroreport},
  year={2000},
  volume={11 3},
  pages={599-602}
}
It has been hypothesized that increased expression of proinflammatory cytokines mediate a variety of central nervous system disorders such as multiple sclerosis, Alzheimer's disease, cerebral ischemia, spinal cord injury, HIV encephalopathy and chronic pain. In order to further examine the central role of TNF in neuropathic pain, transgenic mice were used in which expression of murine TNF was targeted to astrocytes using a glial fibrillary acidic protein (GFAP)-TNF fusion gene. Spinal nerve (L5… CONTINUE READING

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