Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice.

@article{Burkin2005TransgenicEO,
  title={Transgenic expression of \{alpha\}7\{beta\}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice.},
  author={Dean J. Burkin and Gregory Q. Wallace and Derek J. Milner and Eric J. Chaney and James Mulligan and Stephen J. Kaufman},
  journal={The American journal of pathology},
  year={2005},
  volume={166 1},
  pages={253-63}
}
We previously reported that enhanced expression of the alpha7beta1 integrin ameliorates the development of muscular dystrophy and extends longevity in alpha7BX2-mdx/utr(-/-) transgenic mice (Burkin DJ, Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ: Enhanced expression of the alpha7beta1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. We now report on the mechanism by which these mice were rescued by the integrin. As a result of increased integrin in alpha7BX2-mdx… CONTINUE READING

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